Pathway	DB	# genes	p-val	JS	New Dependency	Rewiring	Essentiality Mediators	Specificity Mediators
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	R	14	0.0004	0.9910	0.70	0.26	DPM2 GMPPB PMM1	DOLPP1 DPM2
POST CHAPERONIN TUBULIN FOLDING	R	19	0.0016	0.9950	0.26	0.23	TUBB2A TUBA1B
RNA POL I TRANSCRIPTION INITIATION	R	25	0.0018	0.8169	0.21	0.06	CCNH TAF1B ERCC3	MNAT1
MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	R	10	0.0026	0.8887	0.30	0.26	UBA52 TSG101	NMT2
PRE NOTCH PROCESSING IN GOLGI	R	16	0.0034	0.9765	0.53	0.23	ST3GAL3 NOTCH3	RFNG
DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	R	17	0.0046	0.9790	0.12	0.20	EXOSC4 TNPO1	TNPO1 MAPKAPK2 EXOSC4
ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	R	14	0.0058	0.9656	0.40	0.16	UBA52 RPS27A	E2F3 E2F1
TRNA AMINOACYLATION	R	42	0.0061	0.8992	0.72	0.06	PPA1 WARS2 VARS2	AIMP1 FARS2
TRAFFICKING OF AMPA RECEPTORS	R	28	0.0080	0.9777	0.44	0.05	AP2M1 GRIP2 AP2A2	PRKCB
G PROTEIN ACTIVATION	R	27	0.0125	0.9306	0.03	0.22	GNB5 GNAT2 GNG4 GNB4	POMC GNG12
INSULIN SYNTHESIS AND PROCESSING	R	21	0.0138	0.9458	0.67	0.12	EXOC6 EXOC5	STX1A
REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	R	44	0.0143	0.9663	0.62	0.22	GNG10 PRKACB GNB5 PRKAR1B ADCY1	AQP1 GNG12 RAB11FIP2 ADCY3 GNB1 PRKACB
GLOBAL GENOMIC NER GG NER	R	35	0.0149	0.9941	0.41	0.08	CCNH DDB1 GTF2H4 ERCC5 ERCC2 ERCC3 POLD3 XPC	MNAT1 DDB2 ERCC3 ERCC4
IL1 SIGNALING	R	39	0.0182	0.9519	0.60	0.20	RIPK2 MAP3K8 PELI3 BTRC	PELI2 TAB2 SQSTM1 IKBKG NOD1
LIPID DIGESTION MOBILIZATION AND TRANSPORT	R	46	0.0193	0.9548	0.85	0.15	ABCA1 CETP LPA LDLRAP1	PRKACB P4HB CAV1 FABP4 PPP1CB PLTP LIPC
CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	R	48	0.0278	0.7201	0.04	0.05	RPS27A PSMA5 PSMD9 PSME2 PSME1 PSMD8 PSMD7 PSMD4 PSMD3 PSMD13 PSMD11 PSMC3 PSMC2 PSMC1 PSMB9 PSMB7 PSMB5 PSMB3 PSMB2 PSMB1 PSMB10 PSMA7 PSMA6 PSMA4 PSMA3 PSMA2 PSMF1 PSMD5	CDK2 PSMD12 PSMB6 PSMB8 PSME4
SIGNALING BY NODAL	R	18	0.0298	0.8067	0.47	0.37	DRAP1 LEFTY1	LEFTY2
MICRORNA MIRNA BIOGENESIS	R	23	0.0301	0.9198	0.43	0.14	POLR2E DICER1 POLR2A
IL RECEPTOR SHC SIGNALING	R	27	0.0320	0.2579	0.06	0.08	IL5RA IL2RA IL3RA GRB2 CSF2RB PIK3R3	PIK3CB PIK3R3
EFFECTS OF PIP2 HYDROLYSIS	R	25	0.0341	0.8392	0.85	0.23	ITPR2 PRKCD TRPC3 DAGLB	PRKCQ DGKG TRPC6 DGKD
SEMA3A PAK DEPENDENT AXON REPULSION	R	15	0.0359	0.9925	0.24	0.17	PAK2 CFL1	FYN
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	R	31	0.0384	0.7560	0.49	0.23	GNB5 PLCB2 DLG1	GNG12 CALM2
POST NMDA RECEPTOR ACTIVATION EVENTS	R	33	0.0411	0.9795	0.64	0.20	RPS6KA2 RPS6KA1 CALM2 GRIN2C RASGRF2 PRKACB RPS6KA3 AKAP9 NEFL	BRAF PRKACB ADCY3 MAPK1 CALM2
INTEGRIN ALPHAIIB BETA3 SIGNALING	R	27	0.0432	0.9550	0.28	0.16	FGB AKT1 RAP1A SOS1	SOS1 VWF
SYNTHESIS OF BILE ACIDS AND BILE SALTS	R	19	0.0453	0.8369	0.82	0.05	ACOX2 CYP8B1 CYP7A1 AKR1C4	ACOT8
PRE NOTCH EXPRESSION AND PROCESSING	R	44	0.0493	0.9858	0.72	0.25	B4GALT1 NOTCH3 FURIN SEL1L	MAMLD1 E2F1 MAML3 RFNG ST3GAL3 CCND1 E2F3 MFNG ATP2A3 FURIN
EGFR DOWNREGULATION	R	25	0.0523	0.7722	0.14	0.15	HGS AP2B1 SPRY1 CBL GRB2	SPRY2 RPS27A
ENDOSOMAL VACUOLAR	R	9	0.0545	0.7428	0.54	0.43	HLA-A B2M
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	R	21	0.0609	0.7670	0.39	0.31	B2M AP1B1 AP2M1 CD4	CD28 AP1S1
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	R	22	0.0617	0.6244	0.10	0.14	TUBB2A TUBA1C CCT5	TUBB2A
HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	R	13	0.0627	0.7818	0.49	0.21	PLIN1 PPP1CA
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	R	16	0.0644	0.9986	0.62	0.12	SPCS3 SEC11C SEC11A KLF4
ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	R	37	0.0666	0.9194	0.65	0.19	RPS6KA2 CALM2 RPS6KA1 PRKACB AKAP9	BRAF PRKACB CALM2 MAPK1 ADCY3 HRAS
PURINE CATABOLISM	R	10	0.0683	0.7016	0.83	0.20	NT5C
GLYCOLYSIS	R	29	0.0695	0.9135	0.42	0.21	PPP2CA PFKL GAPDH	ALDOA PFKP PPP2CB
PIP3 ACTIVATES AKT SIGNALING	R	29	0.0696	0.5836	0.62	0.15	CREB1 CDKN1A GSK3A	CASP9 FOXO4 FOXO3
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	R	12	0.0786	0.3548	0.41	0.21	CDKN1A GSK3A	CASP9
GLUCAGON SIGNALING IN METABOLIC REGULATION	R	34	0.0826	0.8394	0.47	0.17	GNG10 ADCY2 ADCY3 GNB4 PRKACB	GNG12 ADCY3 GNB1
CYTOSOLIC SULFONATION OF SMALL MOLECULES	R	14	0.0841	0.8118	0.62	0.22	SULT2B1 SULT2A1	PAPSS1 SULT1A3
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	R	31	0.0841	0.8748	0.98	0.16	SLC35D2 SLC28A3 SLCO3A1	SLC27A4 SLC35D1 SLC35C1 SLC29A1
PEROXISOMAL LIPID METABOLISM	R	21	0.0859	0.8046	0.66	0.21	ACOX2 ACOT8 ACOX1	FAR2 ABCD1 CRAT
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	R	15	0.0901	0.5738	0.76	0.08	ACOX2 CYP8B1 CYP7A1 AKR1C4 SCP2	ACOT8
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	R	15	0.0911	0.4609	0.04	0.18	FGB APBB1IP TLN1	SOS1 VWF
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	R	27	0.0949	0.9839	0.22	0.20	CHMP2A CHMP7 UBA52 TSG101	CHMP4B
PLATELET AGGREGATION PLUG FORMATION	R	36	0.0971	0.8985	0.51	0.19	GP1BA PTK2 GP9 ITGA2B	SOS1 GP5
SYNTHESIS OF PA	R	27	0.0992	0.9346	0.72	0.16	GPAM AGPAT2 AGPAT3	GPD1L AGPAT5 PLA2G12A

Amsterdam

195 norm vs 178 ph